Supersonic turbulence plays an important role in a number of extreme astrophysical and terrestrial environments, yet its understanding remains rudimentary. We use data from a three-dimensional simulation of supersonic isothermal turbulence to reconstruct an exact fourth-order relation derived analytically from the Navier–Stokes equations (Galtier & Banerjee, Phys. Rev. Lett., vol. 107, 2011, p. 134501). Our analysis supports a Kolmogorov-like inertial energy cascade in supersonic turbulence previously discussed on a phenomenological level. We show that two compressible analogues of the four-fifths law exist describing fifth- and fourth-order correlations, but only the fourth-order relation remains ‘universal’ in a wide range of Mach numbers from incompressible to highly compressible regimes. A new approximate relation valid in the strongly supersonic regime is derived and verified. We also briefly discuss the origin of bottleneck bumps in simulations of compressible turbulence.